The CFANS Agroinformatics Initiative encompasses a research partnership between the SBC, InSTePP, and the Minnesota Supercomputing Institute (MSI). This effort leverages public-private partnerships, diverse expertise in plant sciences, bioeconomics, and data analysis, one of the world’s most powerful supercomputers, and large and varied datasets for crop improvement. The Agroinformatics Initiative includes a broad collection of projects led by research teams comprising several different disciplines with the SBC/InSTePP/MSI partnership supporting data access, internal and external relationships, and analytical strategies. The Agroinformatics Initiative specifically focuses on crop improvement in soybean, potato, wheat, corn, oat, apples, and grapes--crops of significance to the Minnesota and U.S. economies and global food security. The Agroinformatics Initiative is supported by CFANS and MnDRIVE Global Food Ventures.